Anxiolytic effects of oxytocin in cue-induced cocaine seeking behavior in rats
Psychopharmacology, ISSN: 1432-2072, Vol: 231, Issue: 21, Page: 4145-4155
2014
- 45Citations
- 61Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations45
- Citation Indexes45
- 45
- CrossRef30
- Captures61
- Readers61
- 61
Article Description
Rationale: Oxytocin (OT) is a neuropeptide previously related to reward, learning, memory, and stress, events associated with cocaine addiction. OT has shown anxiolytic properties in different animal models of anxiety. Moreover, previous data have demonstrated an increase in mRNA OT levels within the nucleus accumbens (NAc) following acute and chronic cocaine exposure in rats. Therefore, OT might play a modulatory role in the rewarding properties of cocaine. Objectives: The present set of experiments aims to examine the role of OT on environmentally elicited cocaine-seeking behavior and whether OT could reduce anxiety associated with this behavior. Conclusions: The present study demonstrates for the first time that OT actions within the brain mediate the anxiety response triggered by cues previously paired with cocaine intake. Methods: Separate groups of rats were trained in a cue-elicited cocaine-seeking behavior paradigm. Prior to the reinstatement phase, animals received microinfusions of artificial cerebrospinal fluid (aCSF), OT, OT agonist (TgOT), or OT antagonist (OTA) within the intracerebral ventricular intracerebroventricular (ICV) system. To test OT anxiolytic effects in reinstatement behavior, separate groups of animals were trained in a cue-elicited cocaine-seeking behavior protocol or in a cocaine-conditioning paradigm. At the end of each behavioral training, all animals were ICV pretreated with aCSF or OT, and then exposed to an elevated plus maze. Results: Results showed that OT and TgOT pretreatment significantly reduced reinstatement of cocaine-seeking behavior. Most significantly, OT treatment reduced the anxiety triggered by cue-induced reinstatement conditions and cocaine-paired conditioned locomotion.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84919752729&origin=inward; http://dx.doi.org/10.1007/s00213-014-3553-y; http://www.ncbi.nlm.nih.gov/pubmed/24760374; http://link.springer.com/10.1007/s00213-014-3553-y; https://dx.doi.org/10.1007/s00213-014-3553-y; https://link.springer.com/article/10.1007/s00213-014-3553-y; https://link.springer.com/content/pdf/10.1007%2Fs00213-014-3553-y.pdf; http://link.springer.com/content/pdf/10.1007/s00213-014-3553-y; http://link.springer.com/article/10.1007%2Fs00213-014-3553-y
Springer Science and Business Media LLC
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