PlumX Metrics
Embed PlumX Metrics

High-throughput, multiparameter analysis of single cells Multiplex Platforms in Diagnostics and Bioanalytics

Analytical and Bioanalytical Chemistry, ISSN: 1618-2650, Vol: 406, Issue: 14, Page: 3279-3296
2014
  • 40
    Citations
  • 0
    Usage
  • 67
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Heterogeneity of cell populations in various biological systems has been widely recognized, and the highly heterogeneous nature of cancer cells has been emerging with clinical relevance. Single-cell analysis using a combination of high-throughput and multiparameter approaches is capable of reflecting cell-to-cell variability, and at the same time of unraveling the complexity and interdependence of cellular processes in the individual cells of a heterogeneous population. In this review, analytical methods and microfluidic tools commonly used for high-throughput, multiparameter single-cell analysis of DNA, RNA, and proteins are discussed. Applications and limitations of currently available technologies for cancer research and diagnostics are reviewed in the light of the ultimate goal to establish clinically applicable assays. [Figure not available: see fulltext.] © 2013 Springer-Verlag Berlin Heidelberg.

Bibliographic Details

Haselgrübler, Thomas; Haider, Michaela; Ji, Bozhi; Juhasz, Kata; Sonnleitner, Alois; Balogi, Zsolt; Hesse, Jan

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know