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Ultra-high-resolution ion mobility spectrometry—current instrumentation, limitations, and future developments

Analytical and Bioanalytical Chemistry, ISSN: 1618-2650, Vol: 411, Issue: 24, Page: 6229-6246
2019
  • 85
    Citations
  • 0
    Usage
  • 87
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    85
  • Captures
    87
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Gas Chromatography and Ion Mobility Spectrometry: A Perfect Match?

Over the past few decades, their outstanding sensitivity and quick response times have allowed ion mobility spectrometers (IMS) to become increasingly popular detectors for gas

Review Description

With recent advances in ionization sources and instrumentation, ion mobility spectrometers (IMS) have transformed from a detector for chemical warfare agents and explosives to a widely used tool in analytical and bioanalytical applications. This increasing measurement task complexity requires higher and higher analytical performance and especially ultra-high resolution. In this review, we will discuss the currently used ion mobility spectrometers able to reach such ultra-high resolution, defined here as a resolving power greater than 200. These instruments are drift tube IMS, traveling wave IMS, trapped IMS, and field asymmetric or differential IMS. The basic operating principles and the resulting effects of experimental parameters on resolving power are explained and compared between the different instruments. This allows understanding the current limitations of resolving power and how ion mobility spectrometers may progress in the future. [Figure not available: see fulltext.].

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