The small neurotoxin apamin blocks not only small conductance Ca activated K channels (SK type) but also the voltage dependent Kv1.3 channel
European Biophysics Journal, ISSN: 1432-1017, Vol: 46, Issue: 6, Page: 517-523
2017
- 19Citations
- 15Captures
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Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef5
- Captures15
- Readers15
- 15
Article Description
Apamin is frequently used as a specific blocker of small-conductance Ca-activated (SK type) K channels. Here we show that the small neurotoxin is not as specific as anticipated. It is also a high-affinity inhibitor with an IC of 13 nM of the Kv1.3 channel; it blocks the latter with potency similar to the Kv1.3 blocker PAP-1. Since SK type channels and Kv1.3 channels are frequently coexpressed in different tissues such as cells of the immune system, apamin must be used with caution as a pharmacological tool.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85009865407&origin=inward; http://dx.doi.org/10.1007/s00249-016-1196-0; http://www.ncbi.nlm.nih.gov/pubmed/28108814; http://link.springer.com/10.1007/s00249-016-1196-0; https://dx.doi.org/10.1007/s00249-016-1196-0; https://link.springer.com/article/10.1007/s00249-016-1196-0
Springer Science and Business Media LLC
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