Clavulanic acid biosynthesis and genetic manipulation for its overproduction
Applied Microbiology and Biotechnology, ISSN: 0175-7598, Vol: 88, Issue: 3, Page: 659-669
2010
- 33Citations
- 81Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations33
- Citation Indexes33
- 33
- CrossRef22
- Captures81
- Readers81
- 81
Article Description
Clavulanic acid, a β-lactamase inhibitor, is used together with β-lactam antibiotics to create drug mixtures possessing potent antimicrobial activity. In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated gene cluster(s) in the main producer species, Streptomyces clavuligerus, has been an intriguing research question. Clavulanic acid biosynthesis was revealed to involve an interesting mechanism common to all of the clavam metabolites produced by the organism, but different from that of other β-lactam compounds. Gene clusters involved in clavulanic acid biosynthesis in S. clavuligerus occupy large regions of nucleotide sequence in three loci of its genome. In this review, clavulanic acid biosynthesis and the associated gene clusters are discussed, and clavulanic acid improvement through genetic manipulation is explained. © Springer-Verlag 2010.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78149357025&origin=inward; http://dx.doi.org/10.1007/s00253-010-2801-2; http://www.ncbi.nlm.nih.gov/pubmed/20711575; http://link.springer.com/10.1007/s00253-010-2801-2; http://www.springerlink.com/index/10.1007/s00253-010-2801-2; http://www.springerlink.com/index/pdf/10.1007/s00253-010-2801-2; https://dx.doi.org/10.1007/s00253-010-2801-2; https://link.springer.com/article/10.1007/s00253-010-2801-2
Springer Science and Business Media LLC
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