In vitro antioxidant activities of Rhodobacter sphaeroides and protective effect on Caco-2 cell line model
Applied Microbiology and Biotechnology, ISSN: 1432-0614, Vol: 103, Issue: 2, Page: 917-927
2019
- 22Citations
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef1
- Captures23
- Readers23
- 23
Article Description
The present study aimed to evaluate the in vitro antioxidant activities and the protective effect of Rhodobacter sphaeroides on HO-induced oxidative stress in Caco-2 cells. The results showed that the antioxidant action of R. sphaeroides varied with different cell concentrations and treatments. Also, the intact cells and intracellular cell-free extracts showed better antioxidant activities. Caco-2 cell–based oxidative stress model was developed by optimizing HO concentration and culture time with the half lethal dose and methyl thiazolyl tetrazolium. By increasing the activity of endogenous antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, upregulating the antioxidant ability of the anti-superoxide anion and anti-hydroxyl radical, R. sphaeroides, especially the mutant strain R. sphaeroides (CGMCC No. 8513), exhibited significant protective activity against HO-induced oxidative stress in Caco-2 cells. Taken together, R. sphaeroides (CGMCC No. 8513) exhibits strong antioxidant activities and is a candidate to be investigated as a potential probiotic in the future.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85056353016&origin=inward; http://dx.doi.org/10.1007/s00253-018-9497-0; http://www.ncbi.nlm.nih.gov/pubmed/30421110; http://link.springer.com/10.1007/s00253-018-9497-0; https://dx.doi.org/10.1007/s00253-018-9497-0; https://link.springer.com/article/10.1007/s00253-018-9497-0
Springer Science and Business Media LLC
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