Total-body [ Ga]Ga-PSMA-11 PET/CT improves detection rate compared with conventional [ Ga]Ga-PSMA-11 PET/CT in patients with biochemical recurrent prostate cancer
European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 1619-7089, Vol: 50, Issue: 13, Page: 4096-4106
2023
- 9Citations
- 6Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations9
- Citation Indexes9
- Captures6
- Readers6
Article Description
Purpose: The purpose of this study was to assess whether total-body [ Ga]Ga-PSMA-11 PET/CT could improve the detection rate compared with conventional [ Ga]Ga-PSMA-11 PET/CT in patients with biochemical recurrent prostate cancer. Methods: Two hundred biochemical recurrent prostate cancer patients with similar clinicopathological characteristics were included, of whom 100 patients underwent early total-body [ Ga]Ga-PSMA-11 PET/CT and diuretic-delayed total-body [ Ga]Ga-PSMA-11 PET/CT, and the other 100 patients received early conventional [ Ga]Ga-PSMA-11 PET/CT and diuretic-delayed conventional [ Ga]Ga-PSMA-11 PET/CT. The detection rates of total-body [ Ga]Ga-PSMA-11 PET/CT and conventional [ Ga]Ga-PSMA-11 PET/CT were compared using a chi-square test and stratified analysis. The image quality of total-body [ Ga]Ga-PSMA PET/CT and conventional [ Ga]Ga-PSMA-11 PET/CT was compared based on subjective scoring and objective parameters. Subjective scoring was conducted from background noise and lesion prominence using a 5-point scale. Objective parameters were evaluated by SUVmax, SUVmean, the standard deviation (SD) of SUV, and the signal-to-noise ratio (SNR) of liver and gluteus maximus. The SUVmax of the recurrent lesions was also measured. Results: The liver SD of the total-body [ Ga]Ga-PSMA-11 PET/CT was significantly lower than that of conventional [ Ga]Ga-PSMA-11 PET/CT, the SNR was significantly higher than that of conventional [ Ga]Ga-PSMA-11 PET/CT, and the subjective evaluation was significantly better than that of conventional [ Ga]Ga-PSMA-11 PET/CT. The detection rate of total-body [ Ga]Ga-PSMA PET/CT for biochemical recurrence of prostate cancer was significantly higher than that of conventional [ Ga]Ga-PSMA-11 PET/CT (91.0% vs. 74.0%, P = 0.003). Total-body [ Ga]Ga-PSMA-11 PET/CT had better detection efficiency for patients with a Gleason score ≤ 8 or PSA ≤ 2 ng/ml. The advantages of diuretic-delayed total-body [ Ga]Ga-PSMA-11 PET/CT were more obvious. Conclusion: Total-body [ Ga]Ga-PSMA-11 PET/CT could significantly improve the detection rate compared with conventional [ Ga]Ga-PSMA-11 PET/CT in patients with biochemical recurrent prostate cancer.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85167903348&origin=inward; http://dx.doi.org/10.1007/s00259-023-06355-5; http://www.ncbi.nlm.nih.gov/pubmed/37578502; https://link.springer.com/10.1007/s00259-023-06355-5; https://dx.doi.org/10.1007/s00259-023-06355-5; https://link.springer.com/article/10.1007/s00259-023-06355-5
Springer Science and Business Media LLC
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