CT perfusion imaging of the liver and the spleen can identify severe portal hypertension

Purpose: To determine if hepatic and splenic perfusion parameters are useful in identifying severe portal hypertension (SPH). Methods: The study enrolled 52 patients who underwent perfusion CT scan within one week before the hepatic venous pressure gradient (HVPG) measurement. A commercial software package was used for post-processing to generate hepatic and splenic perfusion parameters. Correlations were assessed using Pearson and Spearman rank correlation coefficients. Logistic regression was used to screen predictive parameters of SPH. The cut-off values of parameters for severe portal hypertension were calculated, as well as the sensitivity and specificity. Results: There was a significant difference between SPH and non-severe portal hypertension (NSPH) in blood volume of liver (BV), hepatic arterial fraction (HAF), hepatic arterial perfusion (HAP), portal venous perfusion (PVP), mean slope of increase in spleen (MSI), BV, blood flow of spleen (BF), BV, and BV (p < 0.05). The Spearman correlation coefficient was − 0.541 (p < 0.001) between BV and HVPG and − 0.568 (p < 0.001) between BV and HVPG. Using a BV value of 0.780 or BV value of 1.061 as the cut-off value for the detection of SPH, the sensitivity and specificity were 94.7% and 72.7%, 100%, and 63.6% respectively. Conclusion: There was a moderate correlation between CT perfusion parameters BV, BV, and HVPG, which may be used to detect severe portal hypertension. Graphical abstract: (Figure presented.).