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Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: A meta-analysis

International Journal of Colorectal Disease, ISSN: 0179-1958, Vol: 27, Issue: 1, Page: 11-19
2012
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Article Description

Purpose: Although a number of genetic studies have attempted to link organic cation transporter 1/2 (OCTN1/ 2) polymorphisms to susceptibility of Crohn's disease (CD), the results were often inconsistent. The present study aimed at investigating the associations. Methods: The PubMed, EBSCO, and BIOSIS databases were searched to identify eligible studies which were published in English before April 2011. The association was assessed by odds ratio (OR) with 95% confidence intervals (CI). Results: A total of 15 case-control studies, containing 4,489 cases/5,351 controls for OCTN1 and 4,474 cases/5,377 controls for OCTN2 were included. Overall, significant associations were found between OCTN1/2 polymorphisms and susceptibility of Crohn's disease for all genetic models. In the subgroup analyses, significant associations were found in the Caucasian population for OCTN1 (TT vs. CC: OR=1.425, 95% CI 1.247-1.628; TT vs. CT: OR=1.299, 95% CI 1.149-1.468; dominant model: OR=1.344, 95% CI 1.197-1.508; and recessive model: OR=1.179, 95% CI 1.066-1.305) and for OCTN2 (CC vs. GG: OR=1.309, 95% CI 1.078-1.588; CC vs. CG: OR=1.200, 95% CI 1.002-1.438; dominant model (OR=1.231, 95% CI 1.036-1.462; recessive model: OR=1.148, 95% CI 1.031-1.279). Significant associations were not found in the East Asian population. Conclusions: This meta-analysis suggests that OCTN1/2 polymorphisms were associated with susceptibility of CD in the Caucasian population but not in the East Asian population. © 2011 Springer-Verlag.

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