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Prevention of colonic spasm using L-menthol in colonoscopic examination

International Journal of Colorectal Disease, ISSN: 1432-1262, Vol: 29, Issue: 5, Page: 579-583
2014
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Article Description

Purpose: The detailed efficacy of intraluminal l-menthol for preventing colonic spasm is not known. The aim of this study was to evaluate the effectiveness of l-menthol in preventing colonic spasm during colonoscopy. Methods: We analyzed 65 patients (mean age: 71.7 years; 49 men and 16 women) who were administered 0.8 % l-menthol (MINCLEA, Nihon Seiyaku, Tokyo, Japan) intraluminally for severe colonic spasm during colonoscopic examination at Kyoto Prefectural University of Medicine between February 2012 and May 2013. The efficacy of l-menthol was defined as the absence of colonic spasm during a period of 30 s, and its effect was evaluated at 30 s, 1 min, and 5 min after administration. Additionally, various characteristics of these patients were analyzed. Twenty-seven patients with severe colonic spasm were administered intraluminal water and assessed as controls. Results: l-Menthol was effective in preventing colonic spasms in 60.0 %, 70.8 %, and 46.5 % of patients at 30 s, 1 min, and 5 min, respectively. In contrast, water was effective in 22.2 %, 29.6 %, and 48.1 % of patients at 30 s, 1 min, and 5 min, respectively. There was a significant difference about the efficacy at 30 s and 1 min between l-menthol and water (P=0.0009, P=0.0006). Conclusions: l-Menthol (0.8 %) was effective in preventing colonic spasm during colonoscopic examination. © 2014 Springer-Verlag.

Bibliographic Details

Yoshida, Naohisa; Naito, Yuji; Hirose, Ryouhei; Ogiso, Kiyoshi; Inada, Yutaka; Fernandopulle, Nilesh; Kamada, Kazuhiro; Katada, Kazuhiro; Uchiyama, Kazuhiko; Handa, Osamu; Takagi, Tomohisa; Konishi, Hideyuki; Yagi, Nobuaki; Wakabayashi, Naoki; Yanagisawa, Akio; Itoh, Yoshito

Springer Science and Business Media LLC

Medicine

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