Synthesis and characterization of a novel methoxy poly(ethylene glycol)-Tat peptide-chitosan copolymers
Colloid and Polymer Science, ISSN: 0303-402X, Vol: 291, Issue: 6, Page: 1319-1327
2013
- 9Citations
- 12Captures
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Article Description
In this paper, a novel chitosan-g-(-O-methyl poly (ethylene glycol))-g-(-N-Tat peptide) (CS-mPEG-Tat) copolymer was synthesized. The synthesized intermediates and final products were characterized and confirmed by Fourier transform infrared spectrum, H nuclear magnetic resonance spectrum, and X-ray diffraction, respectively. The particle sizes, size distributions, and zeta potentials can also be determined by dynamic light scattering. Agarose gel electrophoresis study showed effective DNA-binding ability of CS-mPEG-Tat. In vitro cytotoxicity assay indicated that CS-mPEG-Tat copolymers were low toxic and cell compatible as the polymer concentration was smaller than 5 mg/ml. This work provides a facile approach to prepare biocompatible PEG-peptide-chitosan copolymer nanoparticles with controllable performances. In conclusion, the obtained CS-mPEG-Tat copolymer might be attractive cationic polymers for nonviral gene therapy. © 2012 Springer-Verlag Berlin Heidelberg.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84878810563&origin=inward; http://dx.doi.org/10.1007/s00396-012-2861-1; http://link.springer.com/10.1007/s00396-012-2861-1; http://link.springer.com/content/pdf/10.1007/s00396-012-2861-1; http://link.springer.com/content/pdf/10.1007/s00396-012-2861-1.pdf; http://link.springer.com/article/10.1007/s00396-012-2861-1/fulltext.html; https://dx.doi.org/10.1007/s00396-012-2861-1; https://link.springer.com/article/10.1007/s00396-012-2861-1
Springer Science and Business Media LLC
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