d-Gluconic acid–based methotrexate prodrug–loaded mixed micelles composed of MDR reversing copolymer: in vitro and in vivo results
Colloid and Polymer Science, ISSN: 1435-1536, Vol: 296, Issue: 12, Page: 1971-1981
2018
- 10Citations
- 10Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
The main aim of the present research was to synthesize carbohydrate (d-gluconic acid, DGA) prodrug of methotrexate (MTX) to improve the aqueous solubility and to develop mixed micelles (MMs) composed of d-α-tocopheryl poly (ethylene glycol) 1000 succinate (TPGS) as an MDR reversing copolymer and poloxamer 407 (P-407) to deliver the MTX prodrug to tumor tissue via enhanced permeability and retention (EPR) mechanism. MTX-DGA conjugate (MDGAC) was synthesized using Steglich esterification reaction. The MDGAC-loaded TPGS and P-407 MMs (MDGAC-TP MMs) were prepared by solvent evaporation technique. MDGAC-TP MMs showed low critical micelle concentration, high drug loading, sustained release profile, lower hemolytic behavior, higher in vitro cytotoxicity against the human carcinoma cell lines KB and MDR KBv, and significantly reduced in vivo toxicity. Therefore, the developed MDGAC-TP MMs could be a promising and effective approach for the development and treatment of MDR tumors. [Figure not available: see fulltext.].
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85055989622&origin=inward; http://dx.doi.org/10.1007/s00396-018-4416-6; http://link.springer.com/10.1007/s00396-018-4416-6; http://link.springer.com/content/pdf/10.1007/s00396-018-4416-6.pdf; http://link.springer.com/article/10.1007/s00396-018-4416-6/fulltext.html; https://dx.doi.org/10.1007/s00396-018-4416-6; https://link.springer.com/article/10.1007/s00396-018-4416-6
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know