Single dose intravenous tranexamic acid as effective as continuous infusion in primary total knee arthroplasty: a randomised clinical trial
Archives of Orthopaedic and Trauma Surgery, ISSN: 1434-3916, Vol: 135, Issue: 4, Page: 465-471
2015
- 59Citations
- 74Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations59
- Citation Indexes58
- 58
- CrossRef43
- Policy Citations1
- Policy Citation1
- Captures74
- Readers74
- 74
Article Description
Introduction: A randomised, double-blind clinical trial was conducted comparing the efficacy of tranexamic acid (TXA) as a single intravenous bolus or a continuous infusion to patients undergoing total knee arthroplasty (TKA). Study hypothesis was that a second dose of TXA would not offer any clinical benefits over the single infusion.Materials and methods: One hundred and six patients were randomised to a single intraoperative dose of 30 mg/kg tranexamic acid (OS group, n = 54), or to a loading dose of 10 mg/kg tranexamic acid followed 2 h later by a continuous 2 mg/kg/h infusion for 20 h (OD group, n = 52). The primary outcome was blood loss calculated from haematological values and perioperative transfusions. Secondary outcomes included the occurrence of major complications within the first postoperative year.Results: All patients completed tranexamic acid therapy without adverse events. The mean blood loss was 1,148 ± 585 ml in group OS and 1,196 ± 614 ml in group OD (p = 0.68). No patients received a transfusion. There were no occurrences of major complications up to 6-weeks follow-up.Conclusions: The study demonstrated that a single bolus of tranexamic acid 30 mg/kg is as effective as a continuous infusion in patients undergoing tranexamic acid. The single application of tranexamic acid as part of routine care is recommended.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84925491230&origin=inward; http://dx.doi.org/10.1007/s00402-015-2168-z; http://www.ncbi.nlm.nih.gov/pubmed/25666288; http://link.springer.com/10.1007/s00402-015-2168-z; https://dx.doi.org/10.1007/s00402-015-2168-z; https://link.springer.com/article/10.1007/s00402-015-2168-z
Springer Science and Business Media LLC
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