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The role of dendritic cells in the immunopathogenesis of psoriasis

Archives of Dermatological Research, ISSN: 0340-3696, Vol: 299, Issue: 8, Page: 359-366
2007
  • 66
    Citations
  • 0
    Usage
  • 60
    Captures
  • 0
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    66
  • Captures
    60
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Review Description

Psoriasis vulgaris is a chronic inflammatory skin disease that is marked by a complex interplay of dendritic cells (DCs), T-cells, cytokines, and downstream transcription factors as part of a self-sustaining type 1 cytokine network. As integral players of the immune system, DCs represent antigen-presenting cells that are crucial for efficient activation of T-cells and B-cells. DCs have also been linked to distinct chronic inflammatory conditions, including psoriasis. In the setting of psoriasis therapy, DC/T cell interactions serve as a potential target for biologic response modifiers. Here we describe the major DC subsets as well as the immunologic involvement of DCs within the context of psoriatic lesions. © 2007 Springer-Verlag.

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