A comparative study of luteal estradiol pre-treatment in GnRH antagonist protocols and in micro dose flare protocols for poor-responding patients
Archives of Gynecology and Obstetrics, ISSN: 1432-0711, Vol: 287, Issue: 1, Page: 149-153
2013
- 20Citations
- 32Captures
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Metrics Details
- Citations20
- Citation Indexes19
- 19
- CrossRef11
- Policy Citations1
- Policy Citation1
- Captures32
- Readers32
- 32
Article Description
Purpose: This study aims to verify if luteal estradiol pre-treatment improves IVF/ICSI outcomes in a GnRH antagonist protocol as compared with a micro dose GnRH agonist protocol in poor-responding patients. Methods: A total of 116 IVF/ICSI cycles were included in this prospective randomized single blind clinical trial. The selected women were randomly assigned to receive an estradiol pre-treatment in a GnRH antagonist protocol (daily oral Estradiol Valerate 4 mg preceding the IVF cycle from the 21st day until the first day of the next cycle) or in oral contraceptive pill micro dose GnRH agonist protocol. Results: The patients in the luteal estradiol protocol required more days of stimulation (10.9 ± 1.6 vs. 10.2 ± 1.8) and a greater gonadotropin requirement (3,247.8 ± 634.6 vs. 2,994.8 ± 611 IU), yet similar numbers of oocytes were retrieved and fertilized. There was no significant difference between the two groups in terms of the implantation rates (9.8 vs. 7.9 %) and the clinical pregnancy rates per transfer (16.3 vs. 15.6 %). Conclusion: This study demonstrates that the use of estradiol during a preceding luteal phase in a GnRH antagonist protocol can provide similar IVF outcomes when compared to a micro dose GnRH agonist protocol. © 2012 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872357251&origin=inward; http://dx.doi.org/10.1007/s00404-012-2522-0; http://www.ncbi.nlm.nih.gov/pubmed/22923150; https://link.springer.com/10.1007/s00404-012-2522-0; https://link.springer.com/article/10.1007%2Fs00404-012-2522-0; http://www.springerlink.com/index/10.1007/s00404-012-2522-0; http://www.springerlink.com/index/pdf/10.1007/s00404-012-2522-0; https://dx.doi.org/10.1007/s00404-012-2522-0; https://link.springer.com/article/10.1007/s00404-012-2522-0; https://link.springer.com/content/pdf/10.1007%2Fs00404-012-2522-0.pdf; http://link.springer.com/10.1007%2Fs00404-012-2522-0; http://link.springer.com/10.1007/s00404-012-2522-0; http://link.springer.com/article/10.1007%2Fs00404-012-2522-0
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