Analysis of sperm telomere length in men with idiopathic infertility
Archives of Gynecology and Obstetrics, ISSN: 0932-0067, Vol: 287, Issue: 4, Page: 803-807
2013
- 83Citations
- 85Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations83
- Citation Indexes83
- 83
- CrossRef32
- Captures85
- Readers85
- 85
Article Description
Purpose: Telomeres are multifunctional nucleoprotein domains with hexanucleotide tandem repeat (5′ TTAGGG 3′) sequences, which cap the chromosome ends. However, the role of telomere and its length in sperm with regard to fertility remains unknown. Methods: In this pilot study, we analyzed 32 idiopathic infertile men and 25 controls for sperm telomere length by quantitative polymerase chain reaction (Q-PCR), and correlated it with sperm DNA fragmentation index (DFI) and reactive oxygen species (ROS) levels. Results: The relative sperm mean telomere length (T/S) of infertile men was found to be significantly lower (p < 0.005) when compared to controls (0.674 ± 0.028 vs. 0.699 ± 0.030). None of the sperm parameters such as sperm count, forward motility, morphology, ROS, and DFI were found to correlate with the sperm telomere length. Conclusion: Shorter telomeres in sperm may be one of the causative factors responsible for male infertility, but further detailed studies are needed to confirm these findings. © 2012 Springer-Verlag Berlin Heidelberg.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84876671168&origin=inward; http://dx.doi.org/10.1007/s00404-012-2632-8; http://www.ncbi.nlm.nih.gov/pubmed/23179801; http://link.springer.com/10.1007/s00404-012-2632-8; https://dx.doi.org/10.1007/s00404-012-2632-8; https://link.springer.com/article/10.1007/s00404-012-2632-8
Springer Science and Business Media LLC
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