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Allergic and idiopathic rhinitis: An ultrastructural study

European Archives of Oto-Rhino-Laryngology, ISSN: 0937-4477, Vol: 266, Issue: 8, Page: 1249-1256
2009
  • 25
    Citations
  • 0
    Usage
  • 20
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    25
  • Captures
    20
  • Mentions
    2
    • News Mentions
      1
      • News
        1
    • References
      1
      • Wikipedia
        1

Most Recent News

Mutual Influence Between Allergic Rhinitis and Sleep: Factors, Mechanisms, and interventions—A Narrative Review

Introduction Allergic rhinitis (AR) is a type I hypersensitivity reaction mediated by immunoglobulin E (IgE). The primary symptoms include nasal congestion, nasal itching, and sneezing.

Article Description

Nasal hyperreactivity is one of the most important underlying mechanisms in both allergic (AR) and idiopathic rhinitis (IR). In order to study the pathomorphological changes in this entity, tissue samples from patients with AR, IR, and from patients without chronic inflammation were taken during nasal surgery. Primary antibodies against Substance P (SP), calcitonin gene-related peptide (CGRP), and endothelial nitric oxide synthases (NOS III) were applied and the immunocomplexes were visualized by immunocytochemistry. The nasal mucosa of patients with AR and IR showed similarities on the ultrastructural level. Neurogenic inflammation was indicated by a strong innervation pattern with sensory nerve fibers containing SP and CGRP. We could show that extensive edema and cellular infiltration might be characteristic for AR. On other hand there was no evidence of eosinophilic or NO involvement in IR. Finally, on the ultrastructural level, AR and IR showed many similarities. Based on these findings anti-inflammatory therapy modalities could be recommended for both types of rhinitis. © 2008 Springer-Verlag.

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