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Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders

European Archives of Psychiatry and Clinical Neuroscience, ISSN: 0940-1334, Vol: 257, Issue: 1, Page: 47-53
2007
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Article Description

Objective: The aim was to investigate the hypothesis that patients with first episode schizophrenic disorders have a more favorable treatment response than those with multiple episodes. Method: A total of 400 inpatients from an ongoing multi-centre, follow-up program who fulfilled ICD-10 criteria for schizophrenic disorders (F2) were assessed at admission to and discharge from hospital using the Positive and Negative Syndrome Scale (PANSS). Results: At admission, first episode patients (n = 121) showed higher levels of positive symptoms (PANSS positive subscore) and lower ones of negative symptoms (PANSS negative subscore) than multiple episode patients (n = 279), whereas the global disease severity (PANSS total score) was comparable. Analyses of covariance revealed that treatment response (adjusted symptom levels at discharge) was more favorable in first-episode patients, with respect to both positive and negative symptoms. Conclusion: The results are compatible with the hypothesis that treatment response becomes less favorable during the course of schizophrenic illness. This finding might be associated with progressive neurobiological alterations. © 2006 Steinkopff Verlag.

Bibliographic Details

Jäger, Markus; Riedel, Michael; Messer, Thomas; Laux, Gerd; Pfeiffer, Herbert; Naber, Dieter; Schmidt, Lutz G; Gaebel, Wolfgang; Huff, Wolfgang; Heuser, Isabella; Kühn, Kai-Uwe; Lemke, Matthias R; Rüther, Eckart; Buchkremer, Gerhard; Gastpar, Markus; Bottlender, Ronald; Strauss, Anton; Möller, Hans-Jürgen

Springer Science and Business Media LLC

Medicine; Neuroscience

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