Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma
Langenbeck's Archives of Surgery, ISSN: 1435-2443, Vol: 394, Issue: 6, Page: 1041-1046
2009
- 8Citations
- 29Captures
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef4
- Captures29
- Readers29
- 29
Article Description
Purpose: The purpose of the study is to evaluate the protective effects of Verapamil on hepatic ischemia-reperfusion injury in cirrhotic patients with HCC. Method: A controlled study was performed on 86 consecutive patients with cirrhosis who underwent liver resection for suffering HCC. Thirty-nine patients were injected with Verapamil through the mesenteric vein before Pringle's maneuver to alleviate hepatic ischemia-reperfusion injury, while 47 patients were not. Results: The serum AST, ALT, and total bilirubin on days 1 and 3 were markedly lower in the Verapamil group than that in the control group postoperatively (AST, P∈<∈0.001 and P∈<∈0.001; ALT, P∈<∈0.001 and P∈=∈0.042; TB, P∈=∈0.037 and 0.049; respectively). The serum hyluronic acid on day 1 was also significantly lower in Verapamil group than that in the control group (P∈<∈0.01), but no marked difference on days 3 and 7. Meanwhile, the levels of IL6 on days 1 and 3 were markedly lower in the Verapamil group than that in control group (P∈<∈0.05 and P∈<∈0.01, respectively. The new Clavien's classification of surgical complications showed marked severity in the control group than that in the Verapamil group (P∈=∈0.021), especially in the grade I level (P∈=∈0.045). Conclusion: Verapamil may serve as protective agent for hepatic ischemia-reperfusion injury in cirrhotic patients with HCC. Therefore, Verapamil can be used for treatment of patients who are to undergo hepatectomy with occlusion of hepatic blood flow. © 2009 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70350336684&origin=inward; http://dx.doi.org/10.1007/s00423-009-0491-y; http://www.ncbi.nlm.nih.gov/pubmed/19350266; http://link.springer.com/10.1007/s00423-009-0491-y; https://dx.doi.org/10.1007/s00423-009-0491-y; https://link.springer.com/article/10.1007/s00423-009-0491-y; http://www.springerlink.com/index/10.1007/s00423-009-0491-y; http://www.springerlink.com/index/pdf/10.1007/s00423-009-0491-y
Springer Science and Business Media LLC
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