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Quality of life over 5 years in women with breast cancer after breast-conserving therapy versus mastectomy: A population-based study

Journal of Cancer Research and Clinical Oncology, ISSN: 0171-5216, Vol: 134, Issue: 12, Page: 1311-1318
2008
  • 158
    Citations
  • 0
    Usage
  • 144
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    158
  • Captures
    144
  • Mentions
    1
    • News Mentions
      1
      • News
        1

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The impact of mastectomy on body image and sexuality in women with breast cancer: a systematic review/El impacto de la mastectomia en la imagen corporal y en la sexualidad de mujeres con cancer de mama: una revision sistematica.

1. Introduction Globally, breast cancer is, excluding non-melanoma skin cancer, the most frequently diagnosed cancer in women, and the commonest cause of cancer death among

Article Description

Purpose: Breast-conserving therapy (BCT) was developed to improve quality of life (QOL) in early stage breast cancer patients. Except for differences in body image, literature comparing the psychosocial sequelae of BCT with mastectomy is ambiguous and shows a lack of substantial benefits. However, knowledge regarding long term effects of treatment on QOL in breast cancer is very limited as most of the pertinent studies have been performed in the early post-operative period. Therefore we compared QOL in women with breast cancer undergoing BCT versus women undergoing mastectomy over a 5-year period following primary surgery. Methods: QOL was assessed at 1, 3, and 5 years after diagnosis in a population based cohort of 315 women with early stage breast cancer (UICC stage I-II) from Saarland (Germany) using the EORTC QLQ-C30 questionnaire and the breast cancer specific module BR23. Results: Breast-conserving therapy was performed in 226 women (72%). After control for potential confounding, women with BCT reported better physical and role functioning, were sexually more active and more satisfied with their body image already at 1 year after diagnosis (all P values < 0.05). Differences in overall QOL and social functioning were gradually increasing over time and became statistically significant only at 5 years. Conclusions: Whereas some, very specific benefits of BCT, such as a better body image, are already visible very timely after completion of therapy, benefits in broader measures such as psychosocial well-being and overall quality of life gradually increase over time and become fully apparent only in the long run. © 2008 Springer-Verlag.

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