Metabolic flux analysis of the sterol pathway in the yeast Saccharomyces cerevisiae
Bioprocess and Biosystems Engineering, ISSN: 1615-7591, Vol: 29, Issue: 4, Page: 241-252
2006
- 21Citations
- 63Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations21
- Citation Indexes21
- 21
- CrossRef16
- Captures63
- Readers63
- 63
Article Description
The yeast Saccharomyces cerevisiae is a useful model system for examining the biosynthesis of sterols in eukaryotic cells. To investigate underlying regulation mechanisms, a flux analysis of the ergosterol pathway was performed. A stoichiometric model was derived based on well known biochemistry of the pathway. The model was integrated in the Software COMPFlux which uses a global optimization algorithm for the estimation of intracellular fluxes. Sterol concentration patterns were determined by gas chromatography in aerobic and anaerobic batch cultivations, when the sterol metabolism was suppressed due to the absence of oxygen. In addition, the sterol concentrations were observed in a cultivation which was shifted from anaerobic to aerobic growth conditions causing the sterol pools in the cell to be filled. From time-dependent flux patterns, possible limitations in the pathway could be localized and the esterification of sterols was identified as an integral part of regulation in ergosterol biosynthesis. © Springer-Verlag 2006.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748702065&origin=inward; http://dx.doi.org/10.1007/s00449-006-0072-1; http://www.ncbi.nlm.nih.gov/pubmed/16838149; http://link.springer.com/10.1007/s00449-006-0072-1; http://www.springerlink.com/index/10.1007/s00449-006-0072-1; http://www.springerlink.com/index/pdf/10.1007/s00449-006-0072-1; https://dx.doi.org/10.1007/s00449-006-0072-1; https://link.springer.com/article/10.1007/s00449-006-0072-1
Springer Science and Business Media LLC
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