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Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines

Pediatric Nephrology, ISSN: 0931-041X, Vol: 21, Issue: 2, Page: 151-159
2006
  • 170
    Citations
  • 0
    Usage
  • 91
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    170
    • Citation Indexes
      160
    • Clinical Citations
      5
      • PubMed Guidelines
        5
    • Policy Citations
      5
      • Policy Citation
        5
  • Captures
    91

Article Description

Childhood renal osteodystrophy (ROD) is the consequence of disturbances of the calcium-regulating hormones vitamin D and parathyroid hormone (PTH) as well as of the somatotroph hormone axis associated with local modulation of bone and growth cartilage function. The resulting growth retardation and the potentially rapid onset of ROD in children are different from ROD in adults. The biochemical changes of ROD as well as its prevention and treatment affect calcium and phosphorus homeostasis and are directly associated with the development of cardiovascular disease in pediatric renal patients. The aims of the clinical and biochemical surveillance of pediatric patients with CRF or on dialysis are prevention of hyperphosphatemia, avoidance of hypercalcemia and keeping the calcium phosphorus product below 5 mmol/I. The PTH levels should be within the normal range in chronic renal failure (CRF) and up to 2-3 times the upper limit of normal levels in dialysed children. Prevention of ROD is expected to result in improved growth and less vascular calcification. © IPNA 2005.

Bibliographic Details

Klaus, G; Watson, A; Edefonti, A; Fischbach, M; Rönnholm, K; Schaefer, F; Simkova, E; Stefanidis, C J; Strazdins, V; Vande Walle, J; Schröder, C; Zurowska, A; Ekim, M; European Pediatric Dialysis Working Group (EPDWG)

Springer Science and Business Media LLC

Medicine

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