Surveillance biopsies in children post-kidney transplant
Pediatric Nephrology, ISSN: 0931-041X, Vol: 27, Issue: 5, Page: 753-760
2012
- 36Citations
- 31Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations36
- Citation Indexes36
- 36
- CrossRef28
- Captures31
- Readers31
- 31
Review Description
Surveillance biopsies are increasingly used in the post-transplant monitoring of pediatric renal allograft recipients. The main justification for this procedure is to diagnose early and presumably modifiable acute and chronic renal allograft injury. Pediatric recipients are theoretically at increased risk for subclinical renal allograft injury due to their relatively large adult-sized kidneys and their higher degree of immunological responsiveness. The safety profile of this procedure has been well investigated. Patient morbidity is low, with macroscopic hematuria being the most common adverse event. No patient deaths have been attributed to this procedure. Longitudinal surveillance biopsy studies have revealed a substantial burden of subclinical immunological and non-immunological injury, including acute cellular rejection, interstitial fibrosis and tubular atrophy, microvascular lesions and transplant glomerulopathy. The main impediment to the implementation of surveillance biopsies as the standard of care is the lack of demonstrable benefit of early histological detection on long-term outcome. The considerable debate surrounding this issue highlights the need for multicenter, prospective, and randomized studies. © IPNA 2012.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863443021&origin=inward; http://dx.doi.org/10.1007/s00467-011-1969-8; http://www.ncbi.nlm.nih.gov/pubmed/21792611; http://link.springer.com/10.1007/s00467-011-1969-8; https://dx.doi.org/10.1007/s00467-011-1969-8; https://link.springer.com/article/10.1007/s00467-011-1969-8; http://www.springerlink.com/index/10.1007/s00467-011-1969-8; http://www.springerlink.com/index/pdf/10.1007/s00467-011-1969-8
Springer Science and Business Media LLC
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