Hepatoprotective and anti-inflammatory potential of chebulagic acid on carbon tetrachloride–induced hepatic fibrosis by antioxidative activities in rats
Comparative Clinical Pathology, ISSN: 1618-565X, Vol: 30, Issue: 6, Page: 961-971
2021
- 2Citations
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Metrics Details
- Citations2
- Citation Indexes2
Article Description
The aim of the present study was to evaluate the hepatoprotective, antioxidant, and anti-inflammatory potential of chebulagic acid on carbon tetrachloride–induced hepatic fibrosis in rats. The liver was damaged in the rats using CCL4 (2 ml/kg b.w dissolved in 20% corn oil) intragastrically twice/week for 8 weeks. After 8 weeks, activities of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase, lipid peroxidation markers, and enzymic and non-enzymic antioxidant enzymes, inflammatory and anti-inflammatory cytokines were analyzed and all these parameters were altered. Chebulagic acid administration reversed all the altered parameters to near-normal levels. Improved histological and immunohistochemical observations liver supported the biochemical investigated. Hence, chebulagic acid exhibits hepatoprotective effects against CCl4-induced liver damage.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85118606392&origin=inward; http://dx.doi.org/10.1007/s00580-021-03295-0; https://link.springer.com/10.1007/s00580-021-03295-0; https://link.springer.com/content/pdf/10.1007/s00580-021-03295-0.pdf; https://link.springer.com/article/10.1007/s00580-021-03295-0/fulltext.html; https://dx.doi.org/10.1007/s00580-021-03295-0; https://link.springer.com/article/10.1007/s00580-021-03295-0
Springer Science and Business Media LLC
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