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Treatment of critical-sized bone defects: clinical and tissue engineering perspectives

European Journal of Orthopaedic Surgery and Traumatology, ISSN: 1432-1068, Vol: 28, Issue: 3, Page: 351-362
2018
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Dini Rachmawati1,2, Tania Saskianti3*, Rini Devijanti Ridwan4, Nenny Prasetyaningrum5,6, Masami Kanawa7 1Doctoral Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, East Java, 60132, Indonesia. 2Department

Review Description

Critical-sized bone defects are defined as those that will not heal spontaneously within a patient’s lifetime. Current treatment options include vascularized bone grafts, distraction osteogenesis, and the induced membrane technique. The induced membrane technique is an increasingly utilized method with favorable results including high rates of union. Tissue engineering holds promise in the treatment of large bone defects due to advancement of stem cell biology, novel biomaterials, and 3D bioprinting. In this review, we provide an overview of the current operative treatment strategies of critical-sized bone defects as well as the current state of tissue engineering for such defects.

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