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Detection of glutathione based on MnO nanosheet-gated mesoporous silica nanoparticles and target induced release of glucose measured with a portable glucose meter

Microchimica Acta, ISSN: 1436-5073, Vol: 185, Issue: 1, Page: 44
2018
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Article Description

The authors describe a novel method for the determination of glutathione (GSH). Detection is based on target induced release of glucose from MnO nanosheet-gated aminated mesoporous silica nanoparticles (MSNs). In detail, glucose is loaded into the pores of MSNs. Negatively charged MnO nanosheets are assembled on the MSNs through electrostatic interactions. The nanosheets are reduced by GSH, and this results in the release of glucose which is quantified by using a commercial electrochemical glucose meter. GSH can be quantified by this method in the 100 nM to 10 μM concentration range, with a 34 nM limit of detection.

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