Electrochemical assays for determination of HO and prostate-specific antigen based on a nanocomposite consisting of CeO nanoparticle-decorated MnO nanospheres
Microchimica Acta, ISSN: 1436-5073, Vol: 187, Issue: 8, Page: 428
2020
- 14Citations
- 11Captures
- 2Mentions
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Article Description
A nanocomposite consisting of CeO nanoparticle-decorated MnO nanospheres (CeO@MnO) was synthesized for the first time via a hydrothermal method. CeO@MnO was exploited to construct an electrochemical assays for detecting HO and prostate-specific antigen (PSA) with square wave voltammetry (SWV). The electrochemical results proved that CeO@MnO owned a better electrocatalytic effect towards HO reduction than pure MnO NS and CeO NP due to the synergistic effect between MnO NS and CeO NP. Under optimized conditions, CeO@MnO-based assay can be applied to detect HO in the range 1 to 3.0 × 10 μmol L. The label-free electrochemical immunoassay based on CeO@MnO displayed linearly with concentrations of PSA from 0.005 to 50.0 ng mL. The electrochemical assays also possessed acceptable sensitivity, selectivity, and stability. The study showed that CeO@MnO hold great potential as a biosensing platform and the clinical determination of tumor markers in human serum. [Figure not available: see fulltext.]
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85087422922&origin=inward; http://dx.doi.org/10.1007/s00604-020-04403-7; http://www.ncbi.nlm.nih.gov/pubmed/32632524; https://link.springer.com/10.1007/s00604-020-04403-7; https://dx.doi.org/10.1007/s00604-020-04403-7; https://link.springer.com/article/10.1007/s00604-020-04403-7
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