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Electrochemical assays for determination of HO and prostate-specific antigen based on a nanocomposite consisting of CeO nanoparticle-decorated MnO nanospheres

Microchimica Acta, ISSN: 1436-5073, Vol: 187, Issue: 8, Page: 428
2020
  • 14
    Citations
  • 0
    Usage
  • 11
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    14
    • Citation Indexes
      14
  • Captures
    11
  • Mentions
    2
    • News Mentions
      2
      • 2

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Article Description

A nanocomposite consisting of CeO nanoparticle-decorated MnO nanospheres (CeO@MnO) was synthesized for the first time via a hydrothermal method. CeO@MnO was exploited to construct an electrochemical assays for detecting HO and prostate-specific antigen (PSA) with square wave voltammetry (SWV). The electrochemical results proved that CeO@MnO owned a better electrocatalytic effect towards HO reduction than pure MnO NS and CeO NP due to the synergistic effect between MnO NS and CeO NP. Under optimized conditions, CeO@MnO-based assay can be applied to detect HO in the range 1 to 3.0 × 10 μmol L. The label-free electrochemical immunoassay based on CeO@MnO displayed linearly with concentrations of PSA from 0.005 to 50.0 ng mL. The electrochemical assays also possessed acceptable sensitivity, selectivity, and stability. The study showed that CeO@MnO hold great potential as a biosensing platform and the clinical determination of tumor markers in human serum. [Figure not available: see fulltext.]

Bibliographic Details

Dai, Yuxue; Wang, Xueying; Zhu, Xiaodong; Liu, Hao; Wang, Pengfei; Wang, Ximei; Zhang, Shaohua; Sun, Yuanling; Gao, Dandan; Han, Rui; Luo, Chuannan

Springer Science and Business Media LLC

Chemistry

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