Lipid rafts play an important role in the vesicular stomatitis virus life cycle
Archives of Virology, ISSN: 0304-8608, Vol: 154, Issue: 4, Page: 595-600
2009
- 17Citations
- 22Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef13
- Captures22
- Readers22
- 22
Article Description
Lipid rafts are involved in the life cycle of many viruses. In this study, we investigated the role of lipids in the life cycle of vesicular stomatitis virus (VSV). Cholesterol depletion by pretreatment of BHK cells or VSV particles with methyl-β-cyclodextrin (MβCD), a cholesterol-sequestering drug, inhibited the production of VSV dramatically. This effect was reversible, and virus production was restored by the addition of cholesterol, indicating that the reduction was caused by the loss of cholesterol in the cell membrane and virus, respectively. Cholesterol depletion at the adsorption stage also reduced the production of VSV significantly, but in contrast, only had a limited effect on virus production at the post-entry stage. Inhibition of sphingomyelin by myriocin treatment only showed a minor effect on VSV production. However, reduction of cholesterol and sphingomyelin at the same time dramatically reduced VSV production, showed a significant synergistic effect. These results suggest that lipid rafts play an important role in the life cycle of VSV. © 2009 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=64249147324&origin=inward; http://dx.doi.org/10.1007/s00705-009-0348-2; http://www.ncbi.nlm.nih.gov/pubmed/19288237; http://link.springer.com/10.1007/s00705-009-0348-2; http://www.springerlink.com/index/10.1007/s00705-009-0348-2; http://www.springerlink.com/index/pdf/10.1007/s00705-009-0348-2; https://dx.doi.org/10.1007/s00705-009-0348-2; https://link.springer.com/article/10.1007/s00705-009-0348-2
Springer Science and Business Media LLC
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