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Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France

Archives of Virology, ISSN: 1432-8798, Vol: 167, Issue: 2, Page: 583-589
2022
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Article Description

We detected SARS-CoV-2 of PANGO lineage R.1 with the spike substitution E484K in three patients. Eleven other sequences in France and 8,831 worldwide were available from GISAID, 92% originating from Japan. The three genome sequences from our institute were phylogenetically closest to another from Guinea-Conakry, where one of the patients had travelled. These viruses did not exhibit any unusual features in cell culture. Spike structural predictions indicated a 1.3-time higher transmissibility index than for the globally spread B.1.1.7 variant but also an affinity loss for gangliosides that might have slowed dissemination. The spread of new SARS-CoV-2 mutants/variants is still not well understood and therefore difficult to predict, and this hinders implementation of effective preventive measures, including adapted vaccines.

Bibliographic Details

Colson, Philippe; Fantini, Jacques; Yahi, Nouara; Delerce, Jeremy; Levasseur, Anthony; Fournier, Pierre-Edouard; Lagier, Jean-Christophe; Raoult, Didier; La Scola, Bernard

Springer Science and Business Media LLC

Immunology and Microbiology

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