Acute transcriptomic changes in murine RAW 264.7 cells following pseudorabies virus infection
Archives of Virology, ISSN: 1432-8798, Vol: 167, Issue: 12, Page: 2623-2631
2022
- 1Citations
- 1Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations1
- Citation Indexes1
- Captures1
- Readers1
Article Description
Next-generation sequencing enables the evaluation of gene expression changes resulting from virus–host interactions at the RNA level. Pseudorabies virus (PRV) causes substantial economic loss in the swine industry. Recent research has revealed that PRV can be transmitted to and infect humans as well. To identify physiopathological and pathological responses post-PRV infection, we characterized transcriptomic changes in the murine RAW 264.7 cell line over the course of 36 h. In total, 156, 153, and 190 differentially expressed genes were identified at 2 h, 12 h, and 36 h, respectively. Seven differentially expressed genes (Trim27, Ccdc117, Mrps12, Ccl4, Cerkl, Ubald1, and Hmga1-rs1) were present across all treatment groups. Our findings expand our knowledge of gene regulation and immune response following PRV infection. These differentially expressed genes can subsequently improve our understanding of PRV pathogenesis.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85140378698&origin=inward; http://dx.doi.org/10.1007/s00705-022-05598-1; http://www.ncbi.nlm.nih.gov/pubmed/36269412; https://link.springer.com/10.1007/s00705-022-05598-1; https://dx.doi.org/10.1007/s00705-022-05598-1; https://link.springer.com/article/10.1007/s00705-022-05598-1
Springer Science and Business Media LLC
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