Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives
Monatshefte fur Chemie, ISSN: 0026-9247, Vol: 145, Issue: 6, Page: 1035-1041
2014
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Article Description
A facile and efficient method for the synthesis of 1,2-dihydropyrrolo[3,4- b]indol-3(4H)-one derivatives via a two-step reaction has been developed. The starting materials of 1H-indole-2-carboxylic acid, aldehyde, and amine are mixed and refluxed in ethanol to generate Mannich products, which are dehydrated in the presence of 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium to form the desired products, 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-ones. Graphical Abstract: [Figure not available: see fulltext.] © 2014 Springer-Verlag Wien.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84901015089&origin=inward; http://dx.doi.org/10.1007/s00706-014-1171-3; http://link.springer.com/10.1007/s00706-014-1171-3; http://link.springer.com/content/pdf/10.1007/s00706-014-1171-3; http://link.springer.com/content/pdf/10.1007/s00706-014-1171-3.pdf; http://link.springer.com/article/10.1007/s00706-014-1171-3/fulltext.html; https://dx.doi.org/10.1007/s00706-014-1171-3; https://link.springer.com/article/10.1007/s00706-014-1171-3
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