Trimesic acid is a suitable building block in triple four-component Ugi reaction: access to unique trivalent compounds
Monatshefte fur Chemie, ISSN: 0026-9247, Vol: 151, Issue: 3, Page: 397-404
2020
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Article Description
Abstract: A triple four-component Ugi reaction of isocyanide, amine, aldehyde, and trimesic acid as the acid component with three acidic functional groups in MeOH at 65 °C has been disclosed. The process employs readily available and low-cost reagents, a convenient synthetic procedure, and mild reaction conditions for the synthesis of pharmacologically significant and structurally interesting compounds with several peptide groups, suitable for dendrimers and self-assembling. Substituents could be independently varied at three different positions. The structural assignments are supported by H and C NMR data. Graphic abstract: [Figure not available: see fulltext.]
Bibliographic Details
Springer Science and Business Media LLC
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