Assessment of blood hemodynamics by USPIO-induced R changes in MRI of murine colon carcinoma
Applied Magnetic Resonance, ISSN: 0937-9347, Vol: 38, Issue: 3, Page: 349-360
2010
- 5Citations
- 15Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations5
- Citation Indexes5
- CrossRef3
- Captures15
- Readers15
- 15
Article Description
The objective of this study is to assess whether ultrasmall superparamagnetic iron oxide (USPIO)-induced changes of the water proton longitudinal relaxation rate (R) provide a means to assess blood hemodynamics of tumors. Two types of murine colon tumors (C26a and C38) were investigated prior to and following administration of USPIO blood-pool contrast agent with fast R measurements. In a subpopulation of mice, R was measured following administration of hydralazine, a well-known blood hemodynamic modifier. USPIO-induced R increase in C38 tumors (ΔR = 0.072 ± 0.0081 s) was significantly larger than in C26a tumors (ΔR = 0.032 ± 0.0018 s, N = 9, t test, P < 0.001). This was in agreement with the immunohistochemical data that showed higher values of relative vascular area (RVA) in C38 tumors than in C26a tumors (RVA = 0.059 ± 0.015 vs. 0.020 ± 0.011; P < 0.05). Following administration of hydralazine, a decrease in R value was observed. This was consistent with the vasoconstriction induced by the steal effect mechanism. In conclusion, R changes induced by USPIO are sensitive to tumor vascular morphology and to blood hemodynamics. Thus, R measurements following USPIO administration can give novel insight into the effects of blood hemodynamic modifiers, non-invasively and with a high temporal resolution. © The Author(s) 2010.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952420858&origin=inward; http://dx.doi.org/10.1007/s00723-010-0124-1; http://www.ncbi.nlm.nih.gov/pubmed/20502507; http://link.springer.com/10.1007/s00723-010-0124-1; https://dx.doi.org/10.1007/s00723-010-0124-1; https://link.springer.com/article/10.1007/s00723-010-0124-1
Springer Nature
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know