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Assessment of blood hemodynamics by USPIO-induced R changes in MRI of murine colon carcinoma

Applied Magnetic Resonance, ISSN: 0937-9347, Vol: 38, Issue: 3, Page: 349-360
2010
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The objective of this study is to assess whether ultrasmall superparamagnetic iron oxide (USPIO)-induced changes of the water proton longitudinal relaxation rate (R) provide a means to assess blood hemodynamics of tumors. Two types of murine colon tumors (C26a and C38) were investigated prior to and following administration of USPIO blood-pool contrast agent with fast R measurements. In a subpopulation of mice, R was measured following administration of hydralazine, a well-known blood hemodynamic modifier. USPIO-induced R increase in C38 tumors (ΔR = 0.072 ± 0.0081 s) was significantly larger than in C26a tumors (ΔR = 0.032 ± 0.0018 s, N = 9, t test, P < 0.001). This was in agreement with the immunohistochemical data that showed higher values of relative vascular area (RVA) in C38 tumors than in C26a tumors (RVA = 0.059 ± 0.015 vs. 0.020 ± 0.011; P < 0.05). Following administration of hydralazine, a decrease in R value was observed. This was consistent with the vasoconstriction induced by the steal effect mechanism. In conclusion, R changes induced by USPIO are sensitive to tumor vascular morphology and to blood hemodynamics. Thus, R measurements following USPIO administration can give novel insight into the effects of blood hemodynamic modifiers, non-invasively and with a high temporal resolution. © The Author(s) 2010.

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