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Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation

Journal of Bone and Mineral Metabolism, ISSN: 0914-8779, Vol: 23, Issue: 5, Page: 337-340
2005
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Sox9 is necessary for chondrogenic differentiation both before and after mesenchymal condensations, while Sox5 and Sox6 are necessary only after mesenchymal condensations. However, no individual Sox is sufficient for the process, since none individually induced the differentiation in various cell types, including ES cells, nonchondrogenic immortalized cells, and nonchondrogenic adult cells. Only when Sox5, Sox6, and Sox9 were combined was the differentiation successfully induced in all cell types and also in vivo, suggesting that the combination provides signals sufficient for the differentiation [27]. The potent in vitro chondrogenic system via the combination of the three Sox genes not only provides a new in vitro chondrogenic differentiation model, which may help us better understand the mechanism of this process, but also adds a powerful tool to cartilage regenerative medicine. © Springer-Verlag 2005.

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