Histological analysis of the ligamentum flavum of patients with dialysis-related spondyloarthropathy
Journal of Orthopaedic Science, ISSN: 0949-2658, Vol: 9, Issue: 3, Page: 285-290
2004
- 12Citations
- 4Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef10
- Captures4
- Readers4
Article Description
Dialysis-related spondyloarthropathy (DRS) is a severe complication of long-term hemodialysis that ultimately leads to functional disability of the upper and lower extremities. Although the cause of this disease is still unknown, it is thought that amyloid deposits are involved. β2-Microglobulin (β2M) is a major component of amyloid fibrils, some of which are modified with the advanced glycation end-product (AGE). To clarify the pathophysiology of DRS we histologically examined the ligamentum flavum of the cervical spine in 15 patients with DRS. The mean duration of hemodialysis was 20 years (12–27 years). In addition to the congo red stain for amyloid, β2M and AGE were detected by immunohistochemical methods. Macrophages were stained with CD68 antibody. Amyloid deposits were found in tissues, although the extent of the stained area differed among the patients. Part of the amyloid deposit area was positively immunostained for β2M and AGE. In 10 cases macrophages positive for CD68 infiltrated around the amyloid deposits. Comparing these histological findings with the dialysis duration, more positive staining areas for β2M and AGE were found in the tissue from patients with long-term dialysis. These findings suggest that both β2M and AGE play roles in the pathogenesis of DRS.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0949265815328621; http://dx.doi.org/10.1007/s00776-004-0767-6; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=3042546495&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15168185; https://linkinghub.elsevier.com/retrieve/pii/S0949265815328621; http://www.springerlink.com/index/10.1007/s00776-004-0767-6; http://www.springerlink.com/index/pdf/10.1007/s00776-004-0767-6; https://dx.doi.org/10.1007/s00776-004-0767-6
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know