Polymorphism in the 3′-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy
Journal of Human Genetics, ISSN: 1434-5161, Vol: 51, Issue: 3, Page: 155-160
2006
- 48Citations
- 14Captures
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Metrics Details
- Citations48
- Citation Indexes48
- 48
- CrossRef37
- Captures14
- Readers14
- 14
Article Description
To investigate the relationship between polymorphism in the 3′-untranslated region (3′-UTR) of the thymidylate synthase (TS) gene and sensitivity of gastric cancer to 5-fluorouracil (5-FU)-based chemotherapy, 106 cases of advanced gastric cancer were analyzed. All patients were treated with 5-FU-based chemotherapy; DNA from peripheral blood leukocytes was obtained before therapy. TS 3′-UTR genotypes were detected by PCR-RFLP. Polymorphism in the TS 3′-UTR can be classified into three groups according to the presence or absence of a 6 bp nucleotide fragment: the -6/-6 bp, -6/+6 bp and +6/+6 bp groups. The response rate of the -6/-6 bp and -6/+6 bp groups was found to be significantly higher than the +6/+6 bp group. These results show that the presence of the TS 3′-UTR 6 bp nucleotide fragment can be correlated with the sensitivity of gastric cancer to 5-FU-based chemotherapy, and that the TS 3′-UTR polymorphism profile can be used to guide the choice of 5-FU-based chemotherapy in advanced gastric cancer. © The Japan Society of Human Genetics and Springer-Verlag 2006.
Bibliographic Details
Springer Science and Business Media LLC
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