Capsaicin suppresses the migration and invasion of human nasopharyngeal carcinoma cells through the modulation of mTOR signaling pathway
Food Science and Biotechnology, ISSN: 2092-6456, Vol: 32, Issue: 13, Page: 1913-1924
2023
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Most Recent News
Studies from Chulabhorn Research Institute Add New Findings in the Area of Nasopharyngeal Carcinoma (Capsaicin Suppresses the Migration and Invasion of Human Nasopharyngeal Carcinoma Cells Through the Modulation of Mtor Signaling Pathway)
2023 MAY 11 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Daily -- Investigators discuss new findings in Oncology - Nasopharyngeal Carcinoma.
Article Description
Nasopharyngeal carcinoma (NPC), a malignancy of the nasopharynx, is prevalent in Southeast Asia and Southern China. The prognosis of NPC is poor and local recurrence and metastasis often occur. Capsaicin (tran-8-methyl-N-vanillyl-6-nonenamide), a pungent constituent of hot chili peppers, shows anti-cancer activities such as anti-proliferation and anti-metastasis. Currently, the role of capsaicin in cell metastasis of NPC is not well understood. We tested whether capsaicin has anti-metastatic activity in NPC cell lines. Capsaicin suppressed cell proliferation in dose-dependent manner. Moreover, capsaicin inhibited cell metastasis as shown by wound healing assay and decreased the expressions of MMP-2 and MMP-9. In addition, the phosphorylation of mTOR was downregulated by capsaicin. Combination of capsaicin and rapamycin (mTOR inhibitor) treatments led to increasing of anti-growth and anti-metastatic activities. Therefore, capsaicin has potential to be used as an optional therapeutic drug for treatment of NPC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85151499601&origin=inward; http://dx.doi.org/10.1007/s10068-023-01297-y; http://www.ncbi.nlm.nih.gov/pubmed/37781054; https://link.springer.com/10.1007/s10068-023-01297-y; https://dx.doi.org/10.1007/s10068-023-01297-y; https://link.springer.com/article/10.1007/s10068-023-01297-y
Springer Science and Business Media LLC
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