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Effects of the onabotulinumtoxinA follow-up delay in migraine course during the COVID-19 lockdown

Neurological Sciences, ISSN: 1590-3478, Vol: 42, Issue: 12, Page: 5087-5092
2021
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Article Description

Background: Face-to-face procedures have been postponed during COVID-19 pandemic. We aim to evaluate the impact of onabotulinumtoxinA follow-up delay in migraine during COVID-19 pandemic. Methods: Subjective worsening, intensity of migraine attacks, and frequency of headache and migraine were retrospectively compared between patients with unmodified and interrupted onabotulinumtoxinA follow-up in Headache Units. Results: We included 67 patients with chronic migraine or high-frequency episodic migraine under onabotulinumtoxinA treatment, 65 (97.0%) female, 44.5 ± 12.1 years old. Treatment administration was voluntarily delayed in 14 (20.9%) patients and nine (13.4%) were unable to continue follow-up. Patients with uninterrupted follow-up during lockdown presented 7.6 and 8.1 less monthly days with headache (adjusted p = 0.017) and migraine attacks (adjusted p = 0.009) compared to patients whose follow-up was interrupted, respectively. Conclusion: Involuntary delay of onabotulinumtoxinA follow-up in patients with migraine due to COVID-19 pandemic was associated with a higher frequency of headache and migraine attacks. Safe administration of onabotulinumtoxinA during lockdown should be promoted.

Bibliographic Details

Gonzalez-Martinez, Alicia; Planchuelo-Gómez, Álvaro; Guerrero, Ángel L; García-Azorín, David; Santos-Lasaosa, Sonia; Navarro-Pérez, María Pilar; Odriozola-González, Paula; Irurtia, María Jesús; Quintas, Sonia; de Luis-García, Rodrigo; Gago-Veiga, Ana Beatriz

Springer Science and Business Media LLC

Medicine

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