Fabrication of Highly Anisotropic and Interconnected Porous Scaffolds to Promote Preosteoblast Proliferation for Bone Tissue Engineering
Chinese Journal of Polymer Science (English Edition), ISSN: 1439-6203, Vol: 39, Issue: 9, Page: 1191-1199
2021
- 6Citations
- 5Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- Captures5
- Readers5
Article Description
Mimicking the complex structure of natural bone remains a challenge for bone tissue scaffolds. In this study, a novel processing strategy was developed to prepare the bone-like scaffolds that are featured by highly oriented and fully interconnected pores. This type of biomimetic scaffolds was evolved from solid phase stretching of immiscible polycaprolactone (PCL)/poly(ethylene oxide) (PEO) blends with co-continuous structure and the pore morphology was inherited from selective extraction of water soluble PEO phase. The pore anisotropy was readily tuned by varying the stretching strain without loss of interconnectivity. Significant promotion in preosteoblast proliferation, alkaline phosphatase activity and osteogenic gene expression was observed in the oriented porous scaffolds compared to the isotropic porous counterpart. The oriented architecture provided a topographical cue for aligned growth of preosteoblasts, which activated the Wnt/β-catenin signaling pathway. The proposed strategy enriches the toolbox for the scaffold design and fabrication for bone tissue engineering.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85106718437&origin=inward; http://dx.doi.org/10.1007/s10118-021-2573-4; https://link.springer.com/10.1007/s10118-021-2573-4; https://link.springer.com/content/pdf/10.1007/s10118-021-2573-4.pdf; https://link.springer.com/article/10.1007/s10118-021-2573-4/fulltext.html; https://dx.doi.org/10.1007/s10118-021-2573-4; https://link.springer.com/article/10.1007/s10118-021-2573-4; http://sciencechina.cn/gw.jsp?action=cited_outline.jsp&type=1&id=7020744&internal_id=7020744&from=elsevier
Springer Science and Business Media LLC
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