Structural Characterization and Immunoenhancing Effects of a Polysaccharide from the Soft Coral Lobophytum sarcophytoides
Marine Biotechnology, ISSN: 1436-2236, Vol: 24, Issue: 1, Page: 203-215
2022
- 2Citations
- 6Captures
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Article Description
Previous studies on the soft coral Lobophytum sarcophytoides (Lobophytum sp.) are mainly about small molecules, and there has been no systematic research on polysaccharides. In the study, a novel polysaccharide (LCPs-1-A) with immunoenhancing functions was successfully extracted and purified from the soft coral Lobophytum sp. After preliminary analysis, our data indicated that LCPs-1-A was composed of glucose and had a molecular weight of 4.90 × 10 Da. Moreover, our findings showed that LCPs-1-A could promote the proliferation and phagocytosis of RAW264.7 cells, stimulate the production of NO and ROS, and increase the mRNA expression of IL-1β, IL-6, and TNF-α, which indicated that LCPs-1-A had a good immunoenhancing activity. Through further studies, we found that LCPs-1-A might play an immunoenhancing role through the TLR4/NF-κB signaling pathway. Therefore, our results demonstrated that LCPs-1-A might be a natural immunostimulant for use in medical and food industries.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85124754602&origin=inward; http://dx.doi.org/10.1007/s10126-022-10099-y; http://www.ncbi.nlm.nih.gov/pubmed/35175461; https://link.springer.com/10.1007/s10126-022-10099-y; https://dx.doi.org/10.1007/s10126-022-10099-y; https://link.springer.com/article/10.1007/s10126-022-10099-y
Springer Science and Business Media LLC
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