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Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: From genome mining to manipulation of biosynthetic pathways

Journal of Industrial Microbiology and Biotechnology, ISSN: 1367-5435, Vol: 41, Issue: 2, Page: 425-431
2014
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Review Description

Heterologous gene expression is one of the main strategies used to access the full biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural product biosynthesis and to create unnatural pathways. Streptomyces coelicolor A3(2) is the most studied member of the actinomycetes, bacteria renowned for their prolific capacity to synthesize a wide range of biologically active specialized metabolites. We review here the use of strains of this species for the heterologous production of structurally diverse actinomycete natural products. © 2013 Society for Industrial Microbiology and Biotechnology.

Bibliographic Details

Gomez-Escribano, Juan Pablo; Bibb, Mervyn J

Oxford University Press (OUP)

Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Immunology and Microbiology

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