Parameterization of hyperpolarized C-bicarbonate-dissolution dynamic nuclear polarization
Magnetic Resonance Materials in Physics, Biology and Medicine, ISSN: 0968-5243, Vol: 28, Issue: 6, Page: 591-598
2015
- 10Citations
- 16Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations10
- Citation Indexes10
- CrossRef10
- 10
- Captures16
- Readers16
- 16
Article Description
Objective: C metabolic MRI using hyperpolarized C-bicarbonate enables preclinical detection of pH. To improve signal-to-noise ratio, experimental procedures were refined, and the influence of pH, buffer capacity, temperature, and field strength were investigated. Materials and methods: Bicarbonate preparation was investigated. Bicarbonate was prepared and applied in spectroscopy at 1, 3, 14 T using pure dissolution, culture medium, and MCF-7 cell spheroids. Healthy rats were imaged by spectral–spatial spiral acquisition for spatial and temporal bicarbonate distribution, pH mapping, and signal decay analysis. Results: An optimized preparation technique for maximum solubility of 6 mol/L and polarization levels of 19–21 % is presented; T and SNR dependency on field strength, buffer capacity, and pH was investigated. pH mapping in vivo is demonstrated. Conclusion: An optimized bicarbonate preparation and experimental procedure provided improved T and SNR values, allowing in vitro and in vivo applications.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84947612721&origin=inward; http://dx.doi.org/10.1007/s10334-015-0500-9; http://www.ncbi.nlm.nih.gov/pubmed/26449715; http://link.springer.com/10.1007/s10334-015-0500-9; https://dx.doi.org/10.1007/s10334-015-0500-9; https://link.springer.com/article/10.1007/s10334-015-0500-9
Springer Science and Business Media LLC
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