Qualitative and quantitative studies on impurities in schizonepetin, a novel antiviral agent, using HPLC, NMR and MS
Chromatographia, ISSN: 0009-5893, Vol: 76, Issue: 9-10, Page: 491-498
2013
- 1Citations
- 8Captures
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Article Description
Schizonepetin is a new naturally occurring monoterpene with antiviral activity. Three unknown related impurities were observed in analysis of schizonepetin bulk drug. A semi-preparative liquid chromatography was used for isolation of the three impurities. Three impurities were characterized as (-)-mintlactone (Impurity I), (R)-(+)-pulegone (Impurity II) and (+)-menthofuran (Impurity III) by a variety of spectral data (IR, UV, MS, H-NMR, C-NMR, DEPT and 2D-NMR). The simultaneous quantitative determination of schizonepetin and its impurities (Imp-I, II and III) was performed by reversed-phase HPLC method with UV detection at 220 nm. The method shows good precision, sensitivity, linearity (between 0.025 and 1.0 mg mL ) and robustness. © 2013 Springer-Verlag Berlin Heidelberg.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84877874365&origin=inward; http://dx.doi.org/10.1007/s10337-013-2424-8; http://link.springer.com/10.1007/s10337-013-2424-8; http://link.springer.com/content/pdf/10.1007/s10337-013-2424-8; http://link.springer.com/content/pdf/10.1007/s10337-013-2424-8.pdf; http://link.springer.com/article/10.1007/s10337-013-2424-8/fulltext.html; https://dx.doi.org/10.1007/s10337-013-2424-8; https://link.springer.com/article/10.1007/s10337-013-2424-8
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