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Respiratory syncytial virus infections

Pneumologe, ISSN: 1613-6055, Vol: 16, Issue: 4, Page: 232-241
2019
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Review Description

Respiratory syncytial virus (RSV) is a seasonally occurring, worldwide distributed airway pathogen and the most common cause for severe bronchiolitis and pneumonia in infants. The RSV affects all age groups but in premature infants, immunodeficient patients and older people over the age of 65 years it is associated with a significant morbidity and mortality. No specific antiviral treatment is so far available and RSV bronchiolitis treatment remains only supportive with oxygen and fluid supplementation and non(invasive) ventilation. A passive immunization with palivizumab, a monoclonal antibody administered during the RSV season, is indicated in high-risk patients for avoidance of severe courses. Currently, however, many novel active RSV vaccines and antiviral substances are being clinically tested and should become available in the upcoming years.

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