Remodeling of engineered tissue anisotropy in response to altered loading conditions
Annals of Biomedical Engineering, ISSN: 0090-6964, Vol: 36, Issue: 8, Page: 1322-1334
2008
- 65Citations
- 87Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations65
- Citation Indexes65
- 65
- CrossRef61
- Captures87
- Readers87
- 87
Article Description
Structural and mechanical anisotropy are critical to the function of many engineered tissues. This study examined the ability of anisotropic tissue constructs to overcome contact guidance cues and remodel in response to altered mechanical loading conditions. Square tissues engineered from dermal fibroblasts and type-I collagen were uniaxially loaded to induce cell and matrix alignment. After an initial time, t*, of 5-72 h, loading was switched from the x-axis to the y-axis. Cell alignment was examined throughout the experiment until a steady state was reached. Before t*, cells spontaneously aligned in the x-direction. After t*, the strength of alignment transiently decreased then increased, and mean cell orientation transitioned from the x- to the y-direction following an exponential time course with a time constant that increased with t*. Collagen fiber orientation exhibited similar trends that could not be explained by passive kinematics alone. Structural realignment resulted in concomitant changes in biaxial tissue mechanical properties. The findings suggest that even highly aligned engineered tissue constructs retain the capacity to remodel in response to altered mechanical stimuli. This may have important functional consequences when an anisotropic engineered tissue designed in vitro is surgically implanted into a mechanically complex graft site. © 2008 Biomedical Engineering Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=49049106510&origin=inward; http://dx.doi.org/10.1007/s10439-008-9509-9; http://www.ncbi.nlm.nih.gov/pubmed/18470621; http://link.springer.com/10.1007/s10439-008-9509-9; http://www.springerlink.com/index/10.1007/s10439-008-9509-9; http://www.springerlink.com/index/pdf/10.1007/s10439-008-9509-9; https://dx.doi.org/10.1007/s10439-008-9509-9; https://link.springer.com/article/10.1007/s10439-008-9509-9
Springer Science and Business Media LLC
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