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Neuropsychological Correlates of Adherence in Youth with Behaviorally Acquired HIV

AIDS and Behavior, ISSN: 1573-3254, Vol: 27, Issue: 11, Page: 3813-3829
2023
  • 1
    Citations
  • 0
    Usage
  • 6
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1
  • Captures
    6
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

New Obesity, Fitness and Wellness Findings from Children's Diagnostic & Treatment Center Discussed (Neuropsychological Correlates of Adherence In Youth With Behaviorally Acquired Hiv)

2023 JUL 31 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity Daily News -- Investigators discuss new findings in Obesity, Fitness and Wellness.

Article Description

Youth living with behaviorally acquired HIV (YLWH) are at-risk for both neuropsychological disorders and antiretroviral therapy (ART) non-adherence; little is known about their interrelationship over time in YLWH. Neuropsychological and psychiatric functioning, substance use, and self-report of 7-day/week and weekend ART adherence were assessed at baseline and Weeks 24, 48, 96 and 144 of a longitudinal study evaluating the impact of early (CD4>350) versus standard of care (CD4≤350) treatment initiation on neuropsychological functioning in 111 treatment-naïve YLWH age 18–24 years at entry. Bayesian multi-level models for adherence (≥ 90% vs. <90%) were fit using random intercepts for repeated measures. Adjusted odds ratios (OR [95% credible interval]) for higher versus lower baseline Motor function for visit adherence were 0.58 (0.25, 1.16), 0.5 (0.15, 1.38), 0.52 (0.16, 1.52), and 0.94 (0.3, 2.8) at Weeks 24, 48, 96, and 144, respectively. Week 24 adherence was associated with higher adjusted odds of Motor function at Week 48 (week: 0.27, -0.05–0.59; weekend: 0.28, -0.07–0.62). Week 96 Complex Executive functioning was associated with higher adjusted odds of adherence at Week 144, OR = 4.26 (1.50, 14.33). Higher Motor functioning emerged most consistently associated with lower odds of adherence in YLWH. Complex Executive functioning was associated with adherence only at end of study, suggesting potential contribution in adherence over the long-term.

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