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Effect of clonidine on potential-dependent sodium currents in sensory neurons

Bulletin of Experimental Biology and Medicine, ISSN: 0007-4888, Vol: 139, Issue: 1, Page: 38-42
2005
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In experiments on rat pups we studied the effect of clonidine on potential-dependent Na currents in dorsal root ganglia by the voltage clamp method. Clonidine decreased the amplitude of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium currents. The range of acting concentrations and the absence of modulatory effect of norepinephrine on the efficiency of clonidine-induced blockade of sodium currents suggest that this blockade results from a direct interaction of clonidine with sodium channels. © 2005 Springer Science+Business Media, Inc.

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