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Effect of ubiquinone Q and antioxidant vitamins on free radical oxidation of phospholipids in biological membranes of rat liver

Bulletin of Experimental Biology and Medicine, ISSN: 0007-4888, Vol: 140, Issue: 2, Page: 181-183
2005
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Article Description

We studied the effects of 30-day peroral treatment with β-carotene, a complex of antioxidant vitamins (vitamins C and E and provitamin A) and selenium, and solubilized ubiquinone Q on the antioxidant potential in rat liver (ascorbate-dependent free radical oxidation of unsaturated membrane phospholipids). β-Carotene irrespective of the administration route increased antioxidant potential of the liver by 2-3.5 times. The complex of antioxidant vitamins and selenium increased this parameter by more than 15 times. Antiradical activity in rat liver was extremely high after administration of solubilized ubiquinone Q (increase by more than by 36 times). It can be expected that reduced ubiquinone Q in vivo should produce a more pronounced protective effect due to activity of the system for bioregeneration of this natural antioxidant. © Springer Science+Business Media, Inc. 2005.

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