Modeling and immunohistochemical analysis of C6 glioma in vivo
Bulletin of Experimental Biology and Medicine, ISSN: 0007-4888, Vol: 143, Issue: 4, Page: 501-509
2007
- 36Citations
- 25Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations36
- Citation Indexes36
- 36
- CrossRef28
- Captures25
- Readers25
- 25
Article Description
A reproducible in vivo model of C6 glioma was developed in Wistar rats. Analysis of histological preparations showed similar morphology of rat C6 glioma and human glioblastoma. The formation of a glial border at the periphery of the glioma, consisting of GFAP-positive reactive astrocytes, was shown by the immunohistochemical method. The border appeared on day 8 after implantation, astrogliosis was observed until animal death (day 28). Reactive astrocytes with branched processes surrounded not only the primary glioma focus, but also all sites of tumor invasion in the nervous tissue. Expression of EBA (blood-brain barrier marker) was disturbed and synthesis of AMVB1 (endothelial antigen) increased in neoplastic endotheliocytes, which suggested pronounced functional restructuring of the blood-tumor barrier in comparison with the blood-brain barrier. The phenomenon of predominant expression of GFAP and AMVB1 in the tumor tissue can be used for the development of systems for targeted drug transport into the tumor by means of appropriate antibodies. © Springer Science+Business Media, Inc. 2007.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34648817551&origin=inward; http://dx.doi.org/10.1007/s10517-007-0167-y; http://www.ncbi.nlm.nih.gov/pubmed/18214311; http://link.springer.com/10.1007/s10517-007-0167-y; http://www.springerlink.com/index/10.1007/s10517-007-0167-y; http://www.springerlink.com/index/pdf/10.1007/s10517-007-0167-y; https://dx.doi.org/10.1007/s10517-007-0167-y; https://link.springer.com/article/10.1007/s10517-007-0167-y
Springer Science and Business Media LLC
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