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Effect of picrotoxin on organism's resistance to acute severe hypoxia

Bulletin of Experimental Biology and Medicine, ISSN: 0007-4888, Vol: 145, Issue: 2, Page: 177-180
2008
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Organism's resistance to acute severe hypoxia (3% O) was studied after administration of GABA receptor antagonist picrotoxin and adenosine receptor antagonist euphylline (aminophylline) and after neutralization of secondary hypocapnia by adding 7% CO to the hypoxic mixture. Administration of picrotoxin to anesthetized rats increased animal resistance to hypoxia. The resistance to hypoxia decreased after treatment with euphylline. Neutralization of secondary hypocapnia by adding 7% CO to the hypoxic mixture had no effect on animal lifespan. © Springer Science+Business Media, Inc. 2008.

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